| dc:title | Functional Mitral Regurgitation Post-Isolated Aortic Valve Replacement |
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| dc:creator | Dabić, Petar |
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| dc:creator | Vucucrevic, Bojan |
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| dc:creator | Sevkovic, Milorad |
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| dc:creator | Andric, Dusan |
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| dc:creator | Pesic, Slobodan |
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| dc:creator | Borovic, Sasa |
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| dc:creator | Petrovic, Jovan |
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| dc:subject | functional mitral regurgitation |
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| dc:subject | isolated aortic valve replacement |
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| dc:subject | prosthesis-patient mismatch |
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| dc:subject | residual mitral regurgitation |
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| dc:subject | natural history (disease) |
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| dc:subject | prognostic factors |
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| dc:subject | transvalvular gradient |
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| dc:subject | aortic valve prosthesis |
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| dc:description | Background: The management of mitral regurgitation during aortic valve replacement remains a complex question. Secondary mitral regurgitation often improves post-aortic valve replacement without mitral valve surgery, but residual mitral regurgitation can significantly affect long-term outcomes. This study investigates the natural history of mitral regurgitation following isolated aortic valve replacement and identifies prognostic factors for persistent mitral regurgitation. Methods: A retrospective study was conducted on 108 patients who underwent isolated aortic valve replacement. Patients were categorized based on mitral regurgitation improvement. Additionally, patients were divided into patient-prosthesis mismatch and non-patient-prosthesis mismatch groups based on the aortic prosthesis. Preoperative and postoperative echocardiographic data were analyzed. Results: In total, 63% of patients showed mitral regurgitation improvement. The improved functional MR group showed significant reductions in peak and mean transvalvular pressure gradients. In contrast, the patient-prosthesis mismatch group had persistent mitral regurgitation improvement in 59.2% of patients. The non-patient-prosthesis mismatch group exhibited significant structural improvements and a reduction in mitral regurgitation severity in 68.6% of patients. Conclusions: The study shows that aortic valve replacement could significantly improve MR when patient-prosthesis mismatch is avoided. This approach maximizes hemodynamic outcomes, mitigates the risk of residual or worsening mitral regurgitation, and potentially reduces the need for additional mitral valve interventions. |
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| dc:publisher | Multidisciplinary Digital Publishing Institute |
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| dc:date | 2024 |
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| dc:type | info:eu-repo/semantics/article |
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| dc:type | info:eu-repo/semantics/publishedVersion |
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| dc:identifier | https://stomatoloskifakultet.rs/nauka/publikacija/808 |
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| dc:identifier | DOI 10.3390/jcm13226971 |
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| dc:identifier | ISSN 2077-0383 |
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| dc:source | Journal of Clinical Medicine 13(22): 6971 |
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| dc:language | en |
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| dc:rights | info:eu-repo/semantics/closedAccess |
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| dc:rights | Sva prava zadržana |
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