| dc:title | Percutaneous Computed Tomography-Guided Oxygen-Ozone (O2O3) Injection Therapy in Patients with Lower Back Pain-An Interventional Two-Year Follow-Up Study of 321 Patients |
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| dc:creator | Davidivic, Kristina |
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| dc:creator | Cotofana, Sebastian |
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| dc:creator | Heisinger, Stephan |
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| dc:creator | Savic, Slavica |
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| dc:creator | Alfertshofer, MIchael |
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| dc:creator | Antonić, Tatjana |
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| dc:creator | Jovanović, Sanja |
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| dc:creator | Ercegovac, Marko |
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| dc:creator | Muto, Mario |
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| dc:creator | Jeremić, Danilo |
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| dc:creator | Janićijević, Aleksandar |
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| dc:creator | Rasulić, Lukas |
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| dc:creator | Janošević, Vesna |
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| dc:creator | Šarić, Lidija |
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| dc:creator | Chua, Deborah |
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| dc:creator | Masulovic, Dragan |
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| dc:creator | Maksimović, Ružica |
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| dc:subject | oxygen-ozone therapy |
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| dc:subject | low back pain |
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| dc:subject | CT-guided injection |
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| dc:subject | corticosteroid injection |
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| dc:subject | intradiscal injection |
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| dc:subject | intervertebral disc degeneration |
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| dc:subject | lumbosacral spine |
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| dc:subject | analgesia |
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| dc:subject | combination therapy |
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| dc:subject | long-term follow-up |
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| dc:description | Objectives: To assess the effect of oxygen-ozone therapy guided by percutaneous Computed Tomography (CT) compared to corticosteroids in individuals experiencing lower back pain (LBP) not attributed to underlying bone-related issues. Methods: A total of 321 patients (192 males and 129 females, mean age: 51.5 ± 15.1 years) with LBP were assigned to three treatment groups: group A) oxygen-ozone only, group B) corticosteroids only, group C) oxygen-ozone and corticosteroids. Treatment was administered via CT-guided injections to the intervertebral disc (i.e., intradiscal location). Clinical improvement of pain and functionality was assessed via self-reported pain scales and magnetic resonance (MR) and CT imaging. Results: At all follow-up times, the mean score of the numeric rating scale and the total global pain scale (GPS) of study groups receiving oxygen-ozone (groups A and C) were statistically significantly lower than the study group receiving corticosteroids only (group B), with p < 0.001. There was a statistically significant difference between groups A and C at 30 days for the numeric rating scale. Conclusions: The percutaneous application of oxygen-ozone in patients with LBP due to degeneration of the lumbosacral spine showed long-lasting significant pain reduction of up to two years post-treatment when compared to corticosteroids alone. Combination therapy of oxygen-ozone and corticosteroids can be useful as corticosteroids showed statistically significant improvement in LBP earlier than the oxygen-ozone-only treatment. |
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| dc:publisher | Multidisciplinary Digital Publishing Institute |
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| dc:date | 2023 |
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| dc:type | info:eu-repo/semantics/article |
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| dc:type | info:eu-repo/semantics/publishedVersion |
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| dc:identifier | https://stomatoloskifakultet.rs/nauka/publikacija/963 |
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| dc:identifier | DOI 10.3390/diagnostics13213370 |
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| dc:identifier | ISSN 2075-4418 |
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| dc:source | Diagnostics 13(21): 3370 |
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| dc:language | en |
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| dc:rights | info:eu-repo/semantics/closedAccess |
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| dc:rights | Sva prava zadržana |
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